Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity
Obesity2016Vol. 24(3), pp. 597–605
Citations Over TimeTop 1% of 2016 papers
Lindsey A. Muir, Christopher K. Neeley, Kevin A. Meyer, Nicki A. Baker, Alice M. Brosius, Alexandra R. Washabaugh, Oliver A. Varban, Jonathan F. Finks, Brian F. Zamarron, Carmen G. Flesher, Joshua Chang, Jennifer B. DelProposto, Lynn M. Geletka, Gabriel Martinez-Santibañez, Niko Kaciroti, Carey N. Lumeng, Robert W. O’Rourke
Abstract
These data are consistent with the hypothesis that adipose tissue fibrosis in the context of human obesity limits adipocyte hypertrophy and is associated with a reciprocal increase in adipocyte hyperplasia, with beneficial effects on systemic metabolism. These findings suggest adipose tissue fibrosis as a potential target for manipulation of adipocyte metabolism.
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