Proteomics analyses of subcutaneous adipocytes reveal novel abnormalities in human insulin resistance
Obesity2016Vol. 24(7), pp. 1506–1514
Citations Over TimeTop 12% of 2016 papers
Xitao Xie, Zhengping Yi, Sandeep Sinha, Meenu Madan, Benjamin P. Bowen, Paul R. Langlais, Danjun Ma, Lawrence J. Mandarino, Christian Meyer
Abstract
These results confirm lower abundance of mitochondrial proteins and suggest increased cytoskeletal proteins and decreased FABP4 and FABP5 in subcutaneous adipocytes of typical IR individuals. Changes in proteins related to lipid metabolism and the unfolded/misfolded protein may discriminate IR and IS individuals of equal adiposity.
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