Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction
Obesity2017Vol. 26(2), pp. 284–290
Citations Over TimeTop 10% of 2017 papers
Deana Mikhalkova, Sujata R. Holman, Hui Jiang, Sultan Ayesh Mohammed Saghir, Eric Novak, Andrew R. Coggan, Robert O’Connor, Adil H. H. Bashir, Ali Jamal, Daniel S. Ory, Jean E. Schaffer, J. Christopher Eagon, Linda R. Peterson
Abstract
Surgery-induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity-related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.
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