Antidepressant Medications and Weight Change: A Narrative Review
Citations Over TimeTop 10% of 2020 papers
Abstract
Antidepressant medications are the first-line treatment option for moderate to severe major depressive disorder. However, most antidepressants have numerous documented adverse events, including cardiometabolic effects and weight gain, which are major public health concerns. Antidepressant agents provide varying risk of associated weight gain, including significant within-class differences. Some agents, such as mirtazapine, show significant levels of weight gain, while others, such as bupropion, demonstrate weight-loss effects. Current findings suggest the role of histamine and serotonin off-target appetite-promoting pathways in adverse weight-gain effects. Therefore, controlling for undesired weight effects is an important consideration for the selection of antidepressants.
Related Papers
- → Effectiveness of a quantitative electroencephalographic biomarker for predicting differential response or remission with escitalopram and bupropion in major depressive disorder(2009)120 cited
- → Can we recommend mirtazapine and bupropion for patients at risk for bleeding?: A systematic review and meta-analysis(2017)32 cited
- → Mirtazapine and Bupropion Combined Treatment in Treatment-resistant Depression(2009)1 cited
- → Quick Antidepressant Effect Seen With Escitalopram/Bupropion Mix(2005)
- Comparison of efficacy and safety of Escitalopram and Mirtazapine in the treatment of depression(2010)