Pathological Society of Great Britain and Ireland. 177th meeting, 1-3 July 1998

Abstract

PTEN, a putative tumour suppressor gene, has been mapped to 10q23.3.Mutations or allelic loss at PTEN have been reported in malignant turnours such as glioblastoma, melanoma, breast, prostate, a n d colorectal carcinomas; germ-line PTEN mutations have also been reported in some juvenile polyposis families.To investigate PTEN in sporadic colorectal adenomas, we examined allele loss (LOH) a t D10S201.D10S215, D10S541 in microdissected tissues from 74 adenomas.Fifty-seven cases were informative, with seven adenomas (12.3%) showing L O H a t one or more loci.The frequencies of L O H in adenomas with mild, moderate a n d severe dysplasia were 6.3% (1/16), 12.0% (3/25 ) a n d 18.8% (3/16), respectively, showing that loss of PTEN m a y be involved in a subset of adenomas.These figures are lower than the frequency of 35% reported in sporadic colorectal carcinomas, a n d generally lower than the accepted 20% threshold for a significant frequency of LOH.Thus, loss of PTEN would appear to be associated with carcinoma rather than adenoma.This is consistent with observations in other tumour types,where FTEN mutation appears related to generally more advanced malignancies.Further work is needed to define the possible =mutations in these positive L O H cases.

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