NAD(P)H:quinone oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia
Pediatric Blood & Cancer2004Vol. 43(5), pp. 568–570
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Sema Sırma, Leyla Ağaoğlu, İnci Yıldız, Dilara Cayli, Emrin Horgusluoglu, Sema Anak, Lebriz Yüksel, Ayşegül Ünüvar, Tiraje Çelkan, Hilmi Apak, Zeynep Karakaş, Ömer Devecioğlu, Uğur Özbek
Abstract
The frequency of homozygosity for NOQ1 C609T polymorphism was 3.5% in the healthy control population and 2.5% in pediatric acute leukemia. The NQO1 C609T allele frequency was not statistically different in the children with acute leukemia in comparison to the controls (odds ratio (OR), 0.76; 95% confidence interval (CI), 0.58-1.01; P = 0.06). The distribution of NQO1 genotypes among children with acute leukemia was not statistically different from the control group (P = 0.13). These findings do not support the role of NQO1 C609T polymorphism in the etiology of de novo pediatric acute leukemia.
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