The pediatric preclinical testing program: Description of models and early testing results
Pediatric Blood & Cancer2006Vol. 49(7), pp. 928–940
Citations Over TimeTop 10% of 2006 papers
Peter J. Houghton, Christopher L. Morton, Chandra L. Tucker, Debbie Payne, Edward Favours, Claire Cole, Richard Görlick, E. Anders Kolb, Wendong Zhang, Richard B. Lock, Hernán Carol, Mimi Tajbakhsh, C. Patrick Reynolds, John M. Maris, Joshua Courtright, Stephen T. Keir, Henry S. Friedman, Charles M. Stopford, Joseph Zeidner, Jianrong Wu, Tiebin Liu, Catherine A. Billups, Javed Khan, Sherry S. Ansher, Jian Zhang, Malcolm A. Smith
Abstract
We have established 51 solid tumor and 10 ALL in vivo models. The models identify vincristine and cyclophosphamide as having broad-spectrum activity. The PPTP tumor panels appear to generally recapitulate the activity of these agents against specific childhood cancers and to have the potential for identifying novel agents having significant clinical activity.
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