Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA
Pediatric Blood & Cancer2011Vol. 56(5), pp. 757–761
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Valérie Combaret, Stéphanie Bréjon, Isabelle Iacono, Gudrun Schleiermacher, Gaëlle Pierron, Agnès Ribeiro, Christophe Bergeron, Aurélien Marabelle, Alain Puisieux
Abstract
Our results show that 17q gain determination in circulating DNA is possible and suggest that this non-invasive test could be useful for very young children when no reliable information on genomic alterations is obtained by aCGH or MPLA analysis of tumor samples This test is complementary to previously developed techniques for detecting circulating MYCN DNA sequences.
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