Dactinomycin and vincristine toxicity in the treatment of childhood cancer: A retrospective study from the Children's Oncology Group
Pediatric Blood & Cancer2010Vol. 57(2), pp. 252–257
Citations Over TimeTop 16% of 2010 papers
Bryan Langholz, Jeffrey Skolnik, Jeffrey S. Barrett, Jamie L. Renbarger, Nita L. Seibel, Anne Zajicek, Carola A.S. Arndt
Abstract
The observed decrease in AMD toxicity rate with cumulative dose may indicate sensitivity in a subgroup of patients while the observed increase in VCR toxicity risk with age may indicate changing sensitivity to VCR. Current dosing practices result in a fairly uniform toxicity profile within age group. However, PK/PD studies should be done to provide further provide further information on best dosing guidelines.
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