Neurobehavioral side effects of corticosteroids during active treatment for acute lymphoblastic leukemia in children are age‐dependent: Report from Dana‐Farber Cancer Institute ALL Consortium Protocol 00‐01
Pediatric Blood & Cancer2011Vol. 57(3), pp. 492–498
Citations Over TimeTop 10% of 2011 papers
Christine Mrakotsky, Lewis B. Silverman, Suzanne E. Dahlberg, M. Cheryl A. Alyman, Stephen A. Sands, Jennifer Queally, Tamara P. Miller, Amy Cranston, Donna Neuberg, Stephen E. Sallan, Deborah P. Waber
Abstract
Preschool children are at greater risk for neurobehavioral side effects during active steroid treatment for ALL than school-age children and adolescents. DEX was not associated with more neurobehavioral side effects than PRED. Counseling of families about side-effects should be adapted according to age. The observed effects, moreover, were transient, reducing concerns about longer-term neurobehavioral toxicities.
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