Bone mineral density among long‐term survivors of childhood acute lymphoblastic leukemia: Results from the St. Jude Lifetime Cohort Study
Pediatric Blood & Cancer2014Vol. 61(7), pp. 1270–1276
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James G. Gurney, Sue C. Kaste, W. Liu, Deo Kumar Srivastava, Wassim Chemaitilly, Kirsten K. Ness, Jennifer Q. Lanctot, Rohit P. Ojha, Kerri Nottage, Carmen L. Wilson, Z. Li, Leslie L. Robison, Melissa M. Hudson
Abstract
Very low BMD was relatively uncommon in this sample of adult survivors of childhood ALL, and BMD Z-scores tended to improve from adolescence to young adulthood. High-dose cranial or craniospinal radiation exposure was the primary predictor of suboptimal BMD in our study. Given that cranial radiation treatment for childhood ALL is used far more sparingly now than in earlier treatment eras, concerns about persistently low BMD among most current childhood ALL patients may be unwarranted.
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