Successful hematopoietic cell transplantation in a patient with X‐linked agammaglobulinemia and acute myeloid leukemia
Pediatric Blood & Cancer2015Vol. 62(9), pp. 1674–1676
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Rolla Abu‐Arja, Leah Chernin, Ghada Abusin, Jeffery J. Auletta, Linda Cabral, Rachel A. Egler, Hans D. Ochs, Troy R. Torgerson, Jesús M. López-Guisa, Robert Hostoffer, Haig Tcheurekdjian, Kenneth R. Cooke
Abstract
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19(+) B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia.
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