Incidence of second cancers after radiotherapy and systemic chemotherapy in heritable retinoblastoma survivors: A report from the German reference center
Pediatric Blood & Cancer2016Vol. 64(1), pp. 71–80
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Petra Temming, Marina Arendt, Anja Viehmann, Lewin Eisele, Claudia H. D. Le Guin, Michael M. Schündeln, Eva Biewald, Kathy Astrahantseff, Regina Wieland, Norbert Bornfeld, W. Sauerwein, Angelika Eggert, Karl‐Heinz Jöckel, Dietmar Lohmann
Abstract
Second cancers remain a major concern in heritable retinoblastoma survivors. Consistent with previous reports, radiotherapy increased second cancer incidence and influenced type and localization. However, chemotherapy was the strongest risk factor for second malignancies outside the periorbital region. Our results provide screening priorities during life-long oncological follow-up based on the curative therapy the patient has received and emphasize the need for less-detrimental therapies for children with heritable retinoblastoma.
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