Vincristine‐induced neuropathy in pediatric patients with acute lymphoblastic leukemia in Oman: Frequent autonomic and more severe cranial nerve involvement
Pediatric Blood & Cancer2017Vol. 64(12)
Citations Over TimeTop 10% of 2017 papers
Hanan Nazir, Amna Al‐Futaisi, Zacharia Mathew, Mohamed Elshinawy, Surekha Tony Mevada, Abdulhakim Al‐Rawas, Doaa Khater, Deepali Jaju, Yasser Wali
Abstract
Peripheral neuropathy was the commonest form of VCR-related neuropathy. Autonomic neuropathy was relatively common in our patients. Cranial neuropathy is a serious side effect of VCR that can be severe, involving multiple cranial nerves and needs prompt recognition and management. Concomitant administration of pyridoxine and pyridostigmine does not seem to protect against further neurological damage in some patients.
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