Burkitt lymphoma in Iraqi children: A distinctive form of sporadic disease with high incidence of EBV+ cases and more frequent expression of MUM1/IRF4 protein in cases with head and neck presentation
Pediatric Blood & Cancer2018Vol. 65(12), pp. e27399–e27399
Citations Over TimeTop 18% of 2018 papers
Stefania Uccini, Mazin Faisal Al‐Jadiry, Claudia Cippitelli, Caterina Talerico, Stefania Scarpino, Amir Fadhil Al‐Darraji, Safa A. Faraj, Adel R. Alsaadawi, Salma A. Al‐Hadad, Luigi Ruco
Abstract
Epstein-Barr virus (EBV)-related lymphoproliferative disorders are relatively common in Iraqi children. Burkitt lymphoma (BL) accounted for 40% of lymphoma cases. The mean age of 125 BL cases was 5.9 ± 3.1 years, and the male-to-female ratio was 3.6:1. Clinical presentation was abdominal in 66% and head and neck in 34%. Bone marrow involvement was higher (P + /CD10+ /MYC+ /BCL2- . MUM1/IRF4 staining was expressed by a fraction of tumor cells in 19 of 125 cases (15%) and was more frequent (P < 0.007) in head and neck disease (12/42; 29%). EBV-encoded RNA was positive in 100 of 125 (80%) BL cases.
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