Rhabdomyosarcoma associated with germline TP53 alteration in children and adolescents: The French experience
Pediatric Blood & Cancer2020Vol. 67(9), pp. e28486–e28486
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Morgane Pondrom, Gaëlle Bougeard, Marie Karanian, Jacynthe Bonneau‐lagacherie, Cécile Boulanger, Hélène Boutroux, Claire Briandet, Christine Chevreau, Nadège Corradini, Carole Coze, Anne Sophie Defachelles, Louise Galmiche-Roland, Daniel Orbach, Christophe Piguet, Jean‐Yves Scoazec, Cécile Verite, Marjolaine Willems, Thierry Frébourg, Véronique Minard‐Colin, Laurence Brugières
Abstract
The high incidence of multiple primary tumors strongly influences the long-term prognosis of RMS associated with TP53 pathogenic germline variants. Anaplastic RMS in childhood, independently of the familial history, should lead to TP53 analysis at treatment initiation to reduce, whenever possible, the burden of genotoxic drugs and radiotherapy in carriers and to ensure the early detection of second malignancies.
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