Reliable prenatal diagnosis of Canavan disease by measuring N‐acetylaspartate in amniotic fluid using liquid chromatography tandem mass spectrometry
Prenatal Diagnosis2009Vol. 29(5), pp. 477–480
Citations Over TimeTop 16% of 2009 papers
Osama Y. Al‐Dirbashi, Wesam Kurdi, Faiqa Imtiaz, Asmahan M. Ahmad, Moeenaldeen Al‐Sayed, Maha Tulbah, Maha Alnemer, Mohamed S. Rashed
Abstract
We developed a new method that enables reliable, sensitive, and selective determination of NAA in a small volume of amniotic fluid for the prenatal diagnosis of Canavan disease. The simple sample preparation adopted in this work precluded the necessity for extraction and derivatization.
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