aCGH on chorionic villi mirrors the complexity of fetoplacental mosaicism in prenatal diagnosis
Prenatal Diagnosis2011Vol. 31(5), pp. 473–478
Citations Over TimeTop 1% of 2011 papers
Isabel Filges, Anjeung Kang, Vanessa Klug, Friedel Wenzel, Karl Heinimann, Sevgi Tercanli, Peter Miny
Abstract
Although interpretation of aCGH results may be straightforward in the majority of cases, placental mosaicism may cause misinterpretations of rapid aCGH results on direct chorionic villi due to discrepant chromosomal constitutions of cytotrophoblast and mesenchymal villus core. Further investigations including cultures, fluorescence in situ hybridization and possible amniocentesis will still be required for interpretation of results.
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