Analysis of false-positive results of fetal RHD typing in a national screening program reveals vanishing twins as potential cause for discrepancy
Prenatal Diagnosis2015Vol. 35(8), pp. 754–760
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Florentine F. Thurik, Aïcha Ait Soussan, Bernadette Bossers, Heleen Woortmeijer, Barbera Veldhuisen, Godelieve C.M.L. Page‐Christiaens, Masja de Haas, C. Ellen van der Schoot
Abstract
These results indicate that false-positive fetal RHD screening results can be caused by cell-free DNA fragments in maternal plasma derived from a third cell line that is not representative for either the maternal genome or the genome of the vital fetus. We propose that remaining (cyto)trophoblasts of a vanishing twin are the underlying mechanism, and we estimate a frequency of this phenomenon of 0.6%.
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