Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism
Prenatal Diagnosis2002Vol. 22(12), pp. 1076–1085
Citations Over TimeTop 10% of 2002 papers
Wendy P. Robinson, Deborah E. McFadden, Irene Barrett, Brian D. Kuchinka, Maria S. Peñaherrera, Hélène Bruyèrè, Robert G. Best, D. A. L. Pedreira, Sylvie Langlois, Dagmar K. Kalousek
Abstract
We infer that amniotic mesenchyme (usually diploid) derives from early embryonic mesoderm of the primitive streak and not from the hypoblast as is commonly cited. Trisomy in amniotic epithelium suggests that high numbers of abnormal cells were present in the epiblast, and this correlates with poor outcome even when the subsequently derived fetus and amniotic mesenchyme appear to carry only diploid cells.
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