Risk estimation of uniparental disomy of chromosome 14 or 15 in a fetus with a parent carrying a non‐homologous Robertsonian translocation. Should we still perform prenatal diagnosis?
Prenatal Diagnosis2019Vol. 39(11), pp. 986–992
Citations Over TimeTop 18% of 2019 papers
Kamran Moradkhani, Laurence Cuisset, Pierre Boisseau, Olivier Pichon, Marine Lebrun, Houda Hamdi‐Rozé, Marie‐Laure Maurin, Nicolas Gruchy, Marie-Christine Manca-Pellissier, Perrine Malzac, Frédéric Bilan, Marie‐Pierre Audrézet, Pascale Saugier-Véber, Anne‐Laure Fauret‐Amsellem, Chantal Missirian, Paul Kuentz, Grégory Egea, Agnès Guichet, Isabelle Creveaux, Caroline Janel, Inès Harzallah, Renaud Touraine, Carole Goumy, Nicole Joyé, Jacques Puechberty, Emmanuelle Haquet, Sandra Chantot‐Bastaraud, Sébastien Schmitt, Philippe Gosset, Bénédicte Duban‐Bedu, Bruno Delobel, Philippe Vago, François Vialard, D. Molina Gomes, Jean‐Pierre Siffroi, Jean‐Paul Bonnefont, Jean‐Michel Dupont, Philippe Jonveaux, Martine Doco‐Fenzy, Damien Sanlaville, Cédric Le Caignec
Abstract
Considering these data, the risk of UPD following prenatal diagnosis of an inherited ROB involving chromosome 14 and/or 15 could be estimated to be around 0.06%, far less than the previous estimation. Importantly, the risk of miscarriage following an invasive prenatal sampling is higher than the risk of UPD. Therefore, we do not recommend prenatal testing for UPD for these pregnancies and parents should be reassured.
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