Huntington disease–unaffected fetus diagnosed from maternal plasma using QF‐PCR
Prenatal Diagnosis2003Vol. 23(3), pp. 232–234
Citations Over TimeTop 10% of 2003 papers
María González‐González, M.J. Trujillo, Marta Rodríguez de Alba, M García-Hoyos, Isabel Lorda‐Sánchez, Joaquín Diaz-Recasens, Carmen Ayuso, Carmen Viana Ramos
Abstract
The discovery of fetal DNA in maternal plasma from early pregnancies has led to new opportunities for clinical application. In the last few years there have been numerous reported applications, mainly fetal gender and RhD genotyping. The prenatal diagnosis of some inherited genetic diseases such as Huntington disease is also very frequently required in the prenatal diagnosis routine. We have successfully diagnosed, with a non-invasive procedure, an unaffected HD fetus at the 13th week of gestation using fetal DNA from maternal plasma and the quantitative fluorescent PCR method, which is one of the most sensitive ways to detect fetal DNA in maternal plasma at such an early time of gestation.
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