High‐Resolution Haplotyping of the PAH Gene Enables Early Gestation Noninvasive Prenatal Diagnosis of Phenylketonuria and Evolution Analysis of Recurrent Pathogenic Variations
Prenatal Diagnosis2024Vol. 44(10), pp. 1198–1209
Jingqi Zhu, Zhenhua Zhao, Shaojun Li, Yifan Zhou, Lingrong Kong, Xinyu Fu, Huanyun Li, Jun Feng, Weiqin Tang, Di Wu, Xiangdong Kong
Abstract
This study validates the feasibility of an RHDO-based assay for NIPD of PKU in early pregnancy and introduces its application in the demonstration of founder effects in recurrent pathogenic variations, offering new insights into the evolutionary analysis of PAH variations.
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