Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms
Prenatal Diagnosis2003Vol. 23(8), pp. 663–668
Citations Over TimeTop 10% of 2003 papers
Abstract
The data provide evidence for several mechanisms leading to aneuploidy, including classical non-disjunction of whole univalents; pre-division of chromatids prior to anaphase I, leading to imbalance detected at metaphase II; gonadal mosaicism for a trisomic cell line and preferential involvement of the smaller chromosomes. Monosomy for the large autosomes is not uncommon in cleavage-stage embryos and may additionally arise from anaphase lag preferentially affecting such chromosomes.
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