Digital PCR Assay Utilizing In‐Droplet Methylation‐Sensitive Digestion for Estimation of Fetal cfDNA From Plasma
Prenatal Diagnosis2025Vol. 45(4), pp. 500–509
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Richard Dannebaum, Olga Mikhaylichenko, David S. Siegel, Chenyu Li, Eric Hall, Séverine Margeridon, Mónica Herrera, Kristin Loomis, Thea Riel, Madhumita Ramesh, Maria F. Gencoglu, Nathan L. Hendel, Anthony Henriquez, Nyari Dzvova, Raymond‐John Abayan, Xinhua Lin, Martin Chavez, Nazeeh Hanna
Abstract
This study showcases the potential of this novel, 6-color, high-multiplex methylation ddPCR panel for accurate measurement of fetal fraction in cfDNA samples. It presents opportunities to integrate such methodology as a standalone measurement to assess the quality of samples undergoing NIPS.
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