Is ketamine infusion effective and safe as an adjuvant of sedation in the PICU? Results from the Ketamine Infusion Sedation Study (KISS)
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy2022Vol. 43(7), pp. 622–631
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Anna Tessari, Francesca Sperotto, Federico Pece, Giulia Pettenuzzo, Nicola Porcellato, Elisa Poletto, Maria Cristina Mondardini, Andrea Pettenazzo, Marco Daverio, Angela Amigoni
Abstract
Ketamine used as a continuous infusion in the PICU might represent a valid strategy to ensure comfort and spare opioids and benzodiazepines in difficult-to-sedate PICU patients. Adverse events are minor and easily reversible. Future study will be needed to investigate long-term outcomes.
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