Proteomic profiling of blood‐dialyzer interactome reveals involvement of lectin complement pathway in hemodialysis‐induced inflammatory response
PROTEOMICS - CLINICAL APPLICATIONS2010Vol. 4(10-11), pp. 829–838
Citations Over TimeTop 25% of 2010 papers
Jan Mareš, Pavlína Richtrová, Alena Hricinova, Zdeněk Tůma, Jiřı́ Moravec, Daniel Lysák, Martin Matějovič
Abstract
ficolin-2 adsorption to polysulfone dialyzer initiates the lectin pathway of complement activation, mediates dialysis-induced leukopenia, and results in a significant depletion of ficolin-2, an essential component of innate immunity.
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