Intraluminal proteome and peptidome of human urinary extracellular vesicles
PROTEOMICS - CLINICAL APPLICATIONS2014Vol. 9(5-6), pp. 568–573
Citations Over TimeTop 24% of 2014 papers
Xinyu Liu, Clizia Chinello, Luca Musante, Marta Cazzaniga, Dorota Tataruch, Giulio Calzaferri, Andrew Smith, Gabriele De Sio, Fulvio Magni, Hequn Zou, Harry Holthöfer
Abstract
Our UEVs preparation protocol provides a simplified way to investigate the intraluminal proteome and peptidome, in particular the subpopulation of UEVs of the trypsin-resistant class of exosomes (positive for tumor susceptibility gene101) and eliminates the majority of interfering proteins such as THP. This method allows the possibility to study endoproteome and endopeptidome of UEVs, thus greatly facilitating biomarker discovery.
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