Insights into Islet Differentiation and Maturation through Proteomic Characterization of a Human iPSC‐Derived Pancreatic Endocrine Model
PROTEOMICS - CLINICAL APPLICATIONS2018Vol. 12(5), pp. e1600173–e1600173
Citations Over TimeTop 20% of 2018 papers
Corinne Haller, Prasad Chaskar, Julie Piccand, Ornella Cominetti, Charlotte Macron, Loı̈c Dayon, Marine R.-C. Kraus
Abstract
Proteomic profiling is valuable to qualify and better understand in vivo maturation of progenitor cells toward β-cells. This is critical for future clinical trials where in vivo maturation still needs to be improved for robustness and effectiveness of cell therapy. Novel biomarkers for predicting the efficiency of maturation represents noninvasive monitoring tools for following efficiency of the implant.
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