Serum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response
PROTEOMICS - CLINICAL APPLICATIONS2019Vol. 14(1), pp. e1900062–e1900062
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Rakesh Arya, Deepti Dabral, Hossain Md. Faruquee, Himangshu Mazumdar, Saurav Jyoti Patgiri, Trinayan Deka, Rumi Basumatary, Rukuwe‐u Kupa, Chayale Semy, Wetetsho Kapfo, Kevideme Liegise, Inderjeet Kaur, Tenzin Choedon, Purnima Kumar, Rajendra Kumar Behera, Pranjal Deori, Reema Nath, Kerekha Khalo, Lahari Saikia, Vinotsole Khamo, Ranjan Kumar Nanda
Abstract
These important proteins, involved in neutrophil degranulation, plasma heme scavenging, kynurenine, and lipid metabolism, show deregulation in ATB patients. Identification of such a protein panel in circulating small EVs besides providing novel insights into their role in tuberculosis may prove to be useful targets to develop host-directed therapeutic intervention.
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