The expression and regulation of ADAMTS‐1, ‐4, ‐5, ‐9, and ‐15, and TIMP‐3 by TGFβ1 in prostate cells: relevance to the accumulation of versican
The Prostate2004Vol. 63(3), pp. 269–275
Citations Over TimeTop 11% of 2004 papers
Neil A. Cross, Shankar Chandrasekharan, N. Jokonya, A. Fowles, Freddie C. Hamdy, David J. Buttle, Colby L. Eaton
Abstract
The induction of versican expression by TGFbeta in BPH stromal cells is in agreement with histological studies. The negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer.
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