Novel multi‐peptide vaccination in Hla‐A2+ hormone sensitive patients with biochemical relapse of prostate cancer
The Prostate2009Vol. 69(9), pp. 917–927
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Susan Feyerabend, Stefan Stevanović, Cécile Gouttefangeas, Dorothee Wernet, Jörg Hennenlotter, Jens Bedke, Klaus Dietz, Steve Pascolo, Markus A. Kuczyk, Hans‐Georg Rammensee, Arnulf Stenzl
Abstract
Multi-peptide vaccination stabilized or slowed down PSA progress in four of 19 cases. The vaccination approach is promising with moderate adverse events. Long-term stability delayed androgen deprivation up to 31 months. TLR-7 co-activation seems to be beneficial.