Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration‐resistant prostate cancer in a mouse xenograft model
The Prostate2009Vol. 70(4), pp. 390–400
Citations Over TimeTop 10% of 2009 papers
Carlos León, Jennifer A. Locke, Hans Adomat, Susan L. Etinger, Alexis L. Twiddy, Rachel D. Neumann, Colleen C. Nelson, Emma S. Tomlinson Guns, Kishor M. Wasan
Abstract
Cellular cholesterol regulation processes are altered during progression to CRPC. Free cholesterol from increased biosynthesis or uptake is likely a precursor for intratumoral de novo androgen synthesis.
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