Metabolic Reprogramming and Validation of Hyperpolarized13C Lactate as a Prostate Cancer Biomarker Using a Human Prostate Tissue Slice Culture Bioreactor
The Prostate2013Vol. 73(11), pp. 1171–1181
Citations Over TimeTop 10% of 2013 papers
Kayvan R. Keshari, Renuka Sriram, Mark Van Criekinge, David M. Wilson, Zhen J. Wang, Daniel B. Vigneron, Donna M. Peehl, John Kurhanewicz
Abstract
We provide the first mechanistic evidence for HP (13) C lactate as a prostate cancer biomarker in living human tissues, critical for the interpretation of in vivo studies. More broadly, the clinically relevant metabolic model system in combination with HP MR can facilitate the identification of clinically translatable biomarkers of prostate cancer presence, aggressiveness, and treatment response.
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