Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis
The Prostate2019Vol. 79(12), pp. 1466–1476
Citations Over TimeTop 10% of 2019 papers
Ligang Zhang, Ligang Zhang, Jing Chen, Jialin Meng, Ligang Zhang, Yi Liu, Changsheng Zhan, Xian‐Guo Chen, Li Zhang, Li Zhang, Chang Yin Liang
Abstract
This study indicated that alcohol could aggravate the severity of prostatic inflammation in EAP model though activating the NLRP3 inflammasome. Furthermore, the role of MCC950 in inhibiting NLRP3 inflammasome and decreasing IL-1β secretion to alleviate EAP severity may show that it is a promising therapeutic agent for CP/CPPS.
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