Plastics degradation by hydrolytic enzymes: Theplastics‐activeenzymes database—PAZy

Citations Over TimeTop 1% of 2022 papers

Abstract

Petroleum-based plastics are durable and accumulate in all ecological niches. Knowledge on enzymatic degradation is sparse. Today, less than 50 verified plastics-active enzymes are known. First examples of enzymes acting on the polymers polyethylene terephthalate (PET) and polyurethane (PUR) have been reported together with a detailed biochemical and structural description. Furthermore, very few polyamide (PA) oligomer active enzymes are known. In this article, the current known enzymes acting on the synthetic polymers PET and PUR are briefly summarized, their published activity data were collected and integrated into a comprehensive open access database. The Plastics-Active Enzymes Database (PAZy) represents an inventory of known and experimentally verified enzymes that act on synthetic fossil fuel-based polymers. Almost 3000 homologs of PET-active enzymes were identified by profile hidden Markov models. Over 2000 homologs of PUR-active enzymes were identified by BLAST. Based on multiple sequence alignments, conservation analysis identified the most conserved amino acids, and sequence motifs for PET- and PUR-active enzymes were derived.

Related Papers

• → Models for polyurethane hydrolysis under moderately acidic conditions: A comparative study of hydrolysis rates of urethanes, ureas, and amides(1989)80 cited
• → Hydrolysis of 1, 3‐dichloropropene in dilute aqueous solution(1987)40 cited
• → Hydrolysis and Formation of CN Bonds(1995)1 cited
• → Hydrolysis of Lipopolysaccharide With Acid(1979)
• Optimized the process of hydrolyzed soybean protein with less MCP(2007)