Ellagitannin (BJA3121), an anti‐proliferative natural polyphenol compound, can regulate the expression of MiRNAs in HepG₂ cancer cells

Citations Over TimeTop 16% of 2009 papers

Abstract

MicroRNAs (miRNAs) play an important role in cancers. A number of miRNA expression-profiling studies have been done to identify the miRNA signatures of cancers from different cellular origin. There is, however, relatively little information on how anticancer agents regulate miRNA expression. Ellagitannin (BJA3121), 1,3-Di-O-galloyl-4,6-(s)-HHDP-b-D-glucopyranose, is a new natural polyphenol compound isolated from Balanophora Japonica MAKINO. Our preliminary results have shown that BJA3121 had antiproliferative effect and modified the expression of different genes in human HepG(2) cancer cells. In this study, we further evaluate whether this antineoplastic compound is able to alter miRNA expression in HepG(2) cells. We demonstrated for the first time that BJA3121 can regulate the expression of 25 miRNAs, including 17 upregulated and 8 downregulated miRNAs in HepG(2) cells. Our results suggested that BJA3121-modifed miRNA expression can mediate, at least in part, the antiproliferative and multigene regulatory action induced by the compound on HepG(2) cancer cells.

Related Papers

• → Punicafolin, an ellagitannin from the leaves of Punica granatum(1985)103 cited
• → Recent progress in ellagitannin chemistry(2004)80 cited
• → Differences in Metabolism of Ellagitannins by Human Gut Microbiota ex Vivo Cultures(2016)59 cited
• → REVIEW: Ellagitannin; biosynthesis, isolation, and biological activities(2003)2 cited
• → Ellagitannin evolution of aged Cognac eaux-de-vie; Impact of barrel toasting(2023)