Evidence that Marine‐derived, Multi‐mineral, Aquamin Inhibits the NF‐κB Signaling Pathway In Vitro
Citations Over TimeTop 10% of 2011 papers
Abstract
It is well established that nuclear factor kappa B (NF-κB) is a central regulator of the immune response and that dysregulation of NF-κB contributes to the pathogenesis of many autoimmune and inflammatory diseases. The food supplement Aquamin is a natural multi-mineral derived from the red algae Lithothamnion corallioides, rich in calcium, magnesium and 72 other trace minerals. This study describes an anti-inflammatory role for Aquamin in inhibiting NF-κB activation through reducing the phosphorylation and degradation of its upstream inhibitor IκBα. Aquamin inhibition of NF-κB activation results in significantly reduced cyclo-oxygenase-2 gene expression following treatment of macrophage cells with lipopolysaccharide. These data suggest that nutritional supplements such as Aquamin may play an important role in regulating the inflammatory response by modulating the nuclear factor kappa B signalling pathway.
Related Papers
- → Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products(2014)30 cited
- → Sanggenon C and O inhibit NO production, iNOS expression and NF-κB activation in LPS-induced RAW264.7 cells(2011)26 cited
- → Malloapelta B suppresses LPS-induced NF-κB activation and NF-κB-regulated target gene products(2014)24 cited
- → An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line(2010)
- Parthenolide attenuates LPS-induced activation of NF-κB in a timedependent manner in rat myocardium(2012)