Puerarin: A Review of Pharmacological Effects
Citations Over TimeTop 1% of 2013 papers
Abstract
Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated. It is available in common foods and is used in alternative medicine. It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic complications, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer. The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance. However, the direct molecular mechanisms and targets remain unclear. This review provides a comprehensive summary of the pharmacological effects of puerarin.
Related Papers
- Determination of Puerarin in Pueraria lobata from Different Areas by HPLC(2000)
- Effect of different particle size on the dissolubility of main active ingredients puerarin in Redix pueraria(2011)
- Study on the Regulation of Dynamic Accumulation of the Puerarin of Pueraria lobata(2011)
- Effect of Radix and Rhizome on the Pharmacokinetics of Puerarin from Tongmai Granules in Rats(2009)
- THE VARIATION OF CONTENT OF PUERARIA ISOFLAVONE AND PUERARIN FROM PUERARIA LOBATA IN THE TAIBI MOUNTAIN WITH DIFFERENT SEASON(2001)