Subunit mass analysis for monitoring multiple attributes of monoclonal antibodies
Rapid Communications in Mass Spectrometry2018Vol. 33(1), pp. 31–40
Citations Over TimeTop 22% of 2018 papers
Peiran Liu, Xin Hao Zhu, Wei Wu, Richard Ludwig, Hangtian Song, Ruojia Li, Jiping Zhou, Li Tao, Anthony Leone
Abstract
The suitability of this MAM for use in a quality control setting is demonstrated through assessment specificity for mAb identity, and accuracy, precision, linearity and robustness for glycan profiling and ratio determination. Results from this study indicate that a MAM with subunit mass analysis has the potential to replace three conventional methods widely used for mAb release testing including identification assay, glycosylation profiling, and ratio determination for co-formulated mAbs.
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