Computational classification of core and outer fucosylation of N‐glycoproteins in human plasma using collision‐induced dissociation in mass spectrometry
Rapid Communications in Mass Spectrometry2020Vol. 34(23), pp. e8917–e8917
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Hoi Keun Jeong, Heeyoun Hwang, Young‐Mook Kang, Hyun Kyoung Lee, Gun Wook Park, Ju Yeon Lee, Dong Geun Kim, Ji‐Won Lee, Sang Yoon Lee, Hyun Joo An, Jin Young Kim, Jong Shin Yoo
Abstract
We established an F-score to classify three different fucosylation types: core, outer, and dual types of N-glycopeptides. The fucosylation types of 20 new N-glycopeptides from 11 glycoproteins in human plasma were classified using the F-score. Therefore, the F-score can be useful for the automatic classification of different types of fucosylation in N-glycoproteins of biological fluids including plasma, serum, and urine.
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