Sex‐based differences in severity and mortality in COVID‐19
Reviews in Medical Virology2021Vol. 31(6), pp. e2223–e2223
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Mustafa Alwani, Aksam Yassin, Raed M. Al‐Zoubi, Omar M. Aboumarzouk, Joanne E. Nettleship, Daniel Kelly, Ahmad R. Al‐Qudimat, Ridwan Shabsigh
Abstract
The current coronavirus disease (COVID-19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS-CoV and MERS-CoV, and viral infections in general. Here, we discuss the sex-disaggregated epidemiological data for COVID-19 and highlight underlying differences that may explain the sexual dimorphism to help inform risk stratification strategies and therapeutic options.
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