Clinical features of variant Creutzfeldt‐Jakob disease

Citations Over TimeTop 20% of 2002 papers

Abstract

Since 1996, over one hundred cases of variant Creutzfeldt-Jakob disease have appeared, mostly in the United Kingdom. In this review, we summarise the major clinical features of this progressive neurodegenerative condition and compare them with those of sporadic Creutzfeldt-Jakob disease. We emphasise the young age (median 26 years) at presentation and the dominant psychiatric/behavioural features, particularly depression. Sensory symptoms are present initially in half the cases and florid psychiatric symptoms, such as delusions or hallucinations, are also common. Given these symptoms, many patients present in clinical practice initially to a psychiatrist but are referred to neurologists when neurological signs become apparent. Although the definitive diagnosis remains neuropathological, a confident pre-mortem diagnosis is now possible when the 'pulvinar sign' is seen on magnetic resonance imaging studies.

Related Papers

• [The incidence of reversible dementia in 145 patients referred on suspicion of dementia].(2002)
• → Selecting Your Presentation Strategies(2010)
• → 3. Producing a persuasive presentation(2010)
• → EXCELLENT ELEMENTS OF PRESENTATION IN BUSINESS ARENA(2023)
• → Presentation Skills(2023)