‘Mendelian randomization’ equals instrumental variable analysis with genetic instruments
Statistics in Medicine2008Vol. 27(15), pp. 2745–2749
Citations Over TimeTop 10% of 2008 papers
Abstract
Interest in instrumental variable (IV) analyses using genetic instruments has been growing over the past 4 years. The background, strength and weaknesses of this approach, which in the epidemiology literature has been referred to as 'Mendelian randomization', has been recently reviewed by Lawlor et al. (Statist. Med. 2007. DOI: 10.1002/sim.3034). We suggest a change in the nomenclature of 'Mendelian randomization' and discuss issues relevant to IV analysis including instrument validation, motivation of IV analysis and interpretation of IV estimates in order to motivate a more consistent and standard use of IV analysis across applications using genetic instruments.
Related Papers
- → Inference of a causal relation between low-density lipoprotein cholesterol and hypertension using mendelian randomization analysis(2021)8 cited
- → On the use of kernel machines for Mendelian randomization(2017)9 cited
- → Re: "Credible Mendelian Randomization Studies: Approaches For Evaluating The Instrumental Variable Assumptions"(2012)9 cited
- → Constrained Instruments and their Application to Mendelian Randomization with Pleiotropy(2017)7 cited