Synthesis of Bicyclic Ortho‐Amino Carbonitriles Catalyzed by [BMIM]Ac Ionic Liquid: A Green Chemistry Approach
Abstract
Abstract A task‐specific ionic liquid, 1‐butyl‐3‐methylimidazolium acetate ([BMIM]Ac), has been demonstrated as an efficient and sustainable catalyst for the synthesis of bicyclic ortho‐amino carbonitrile derivatives under ambient conditions. The key advantage of this protocol lies in the use of a mild basic ionic liquid, which effectively regulates the reaction, preventing side product formation, and ensuring a direct and selective transformation. Additionally, this method offers several benefits, including high product yields, short reaction times, and the recyclability of the ionic liquid, making it a cost‐effective and environmentally friendly approach. Furthermore, a detailed reaction mechanism has been proposed to provide insight into the catalytic process. Green metrics analysis has also been carried out to assess environmental effect and sustainability of this protocol.
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