Chiral Metallo-Supramolecular Complex Directed Enantioselective Self-Assembly of β-Sheet Breaker Peptide for Amyloid Inhibition

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Abstract

Chiral recognition plays an important role for biomacromolecules involved self-assembly and further affects their biological functions. Herein, it is demonstrated that two chiral metal complexes can enantioselectively bind with Aβ15-20, leading to the formation of different self-assembled nanostructures. With the ability of both metal complexes and Aβ15-20 to inhibit Aβ1-40 aggregation, the NiM@P hybrid particles can act as bifunctional Aβ inhibitors.

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