Extracellular vesicles derived from fibroblasts promote wound healing by optimizing fibroblast and endothelial cellular functions
Citations Over TimeTop 10% of 2020 papers
Abstract
Extracellular vesicles (EVs) have been exhibited as promising candidates for delivering endogenous therapeutic cargos for regenerative therapies. Fibroblasts could be candidate source cells for EVs, to investigate their therapeutic effects in wound healing. Here we demonstrated the isolation and characterization of fibroblast-derived (L929 cell line) EVs (L929-EVs). Furthermore, L929-EVs treatment showed pro-wound healing effects in vitro by enhancing proliferation, migration, and scarless wound healing related genes in fibroblast cells. L929-EVs treatment also enhanced the migration and tube formation of endothelial cells. The combination of L929-EVs with fibrin glue accelerated wound healing in the mouse skin wound model by enhancing collagen formation, collagen maturation, and blood vessels in the wounded skin. The role of fibroblast-derived EVs in wound healing could be an important phenomenon, and fibroblast-derived EVs could be harnessed for wound healing therapies.
Related Papers
- → The Role of Extracellular Matrix in Wound Healing(2023)30 cited
- → Effects of elevated glucose levels on interactions of cardiac fibroblasts with the extracellular matrix(2007)25 cited
- → Effects of Danchisoyo-san on UVB-induced Cell Damage and Gene Expression in Dermal Fibroblast(2011)3 cited
- Effects of Kwibi-tang on Dermal Fibroblast(2011)
- Effects of Kanghwalsokdan-tang on Dermal Fibroblast(2012)