Upregulation of striatal adenosine A2A receptor mRNA in 6‐hydroxydopamine‐lesioned rats intermittently treated with L‐DOPA
Synapse2004Vol. 52(3), pp. 218–222
Citations Over TimeTop 10% of 2004 papers
Abstract
To determine whether the adenosine A2A receptor might play a role in L-DOPA-induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A2A receptor mRNA in response to intermittent treatment with L-DOPA in rats with dopaminergic denervation by 6-hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L-DOPA increased A2A receptor mRNA levels in the dopamine-depleted striatum of 6-OHDA-lesioned rats exhibiting behavioral sensitization to L-DOPA. These results suggest that A2A receptor activation is associated with the development of motor complications induced by L-DOPA treatment.
Related Papers
- → Striatal G-proteins: Effects of unilateral 6-hydroxydopamine lesions(1994)40 cited
- → Time-dependent Striatal Dopamine Depletion after Injection of 6-Hydroxydopamine in the Rat. Comparison of Single Bilateral and Double Bilateral Lesions(1999)19 cited
- → 6-Hydroxydopamine: Effect on mouse brain monoamines and 14C-noradrenaline uptake(1973)10 cited
- → 2.415 Use of an optimized striatal and medial forebrain bundle 6-hydroxydopamine rat model for Parkinson's disease in the search for neuroprotective drugs(2007)
- Differential molecular and behavioural response to L-DOPA in mice injected with 6-hydroxydopamine in the striatum or in the medial forebrain bundle(2010)