PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[11C]O-methylreboxetine and HRRT
Synapse2009Vol. 64(1), pp. 30–38
Citations Over TimeTop 10% of 2009 papers
Yu‐Shin Ding, Tarun Singhal, Beata Planeta‐Wilson, Jean‐Dominique Gallezot, Nabeel Nabulsi, David Labaree, Jim Ropchan, Shannan Henry, Wendol Williams, Richard E. Carson, Alexander Neumeister, Robert T. Malison
Abstract
Our results suggest that (a) brain NET concentration declines with age in HC, and (b) there is a significant upregulation of NET in thalamus and dorsomedial thalamic nucleus in COC as compared to HC. Our results also suggest that the use of [(11)C]MRB and HRRT provides an effective strategy for studying alterations of the NET system in humans.
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