Unexpected toxicity of very low dose MPTP in mice: A clue to the etiology of Parkinson's disease?
Citations Over TimeTop 22% of 2015 papers
Abstract
Although much progress have been made in recent years, the etiology of idiopathic Parkinson's disease remains obscure. The chance discovery that injection of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a syndrome very similar to parkinsonism introduced the "environmental toxin" hypothesis but no toxin was ever found in any quantity in patients' brains. We have unexpectedly now found, however, that, in mice, very low doses of MPTP induce as much dopaminergic neuronal death as far higher doses. Cellular detoxification mechanisms would appear to be incapacitated at such low doses. This could infer that the barely discernible presence of an unidentified neurotoxin may be responsible for the onset of Parkinson's disease.
Related Papers
- → Mild parkinsonism in persons exposed to 1‐methyl‐4‐phenyl‐1,2,3,6‐ tetrahydropyridine (MPTP)(1989)53 cited
- → Similarity and Dissimilarity of MPTP Models to Parkinson’s Disease: Importance of Juvenile Parkinsonism(1987)9 cited
- → Endogenous MPTP-Like Amines in the Brain: Isoquinolines(1994)1 cited
- → Complex I Deficiency in Parkinson’s Disease and MPTP-Induced Experimental Parkinsonism(1990)1 cited
- [Evaluation of the capability of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pyridine derivatives to evoke parkinsonism].(1989)